(2025-11-01) Digital Health 50 The Most Promising Digital Health Startups Of 2025

CB Insights Research: Digital Health 50: The most promising digital health startups of 2025.

Competition is ramping up within digital health.

• Deal volume has dropped consistently since 2021, raising the stakes for all players. Emerging startups need clear differentiation and proven traction to secure funding.
• private companies with strong growth potential, focusing on early-stage players with strong market traction, high-quality investors, and growing teams.

Below, we map out the winners based on their core offering and highlight key trends from this year’s cohort

Key Takeaways on the Digital Health 50

1. Healthcare is shifting from reactive to preventive care, with earlier detection and remote access redefining when and where intervention occurs

*Multiple companies on this year’s list are enabling earlier disease detection through AI-powered diagnostics, comprehensive health screenings, and continuous monitoring. These include cardiovascular disease prediction from ECG data (Anumana), full-body preventive scans (Function Health, Neko Health), and at-home diagnostic testing (PocDoc, Teal Health).

Virtual and telehealth platforms are making preventive and specialty care more accessible by bringing clinical expertise outside hospitals and clinics. These companies provide 24/7 access to specialized services like neurology (Sevaro, Isaac Health), maternal health (Delfina), and nutrition counseling (Nourish, Fay Nutrition), while others are removing geographic barriers through mobile and home-based care (Sprinter Health).*

2. Workflow automation tools are tackling provider burnout and workforce shortages

Physician burnout costs the US healthcare system an estimated $4.6B annually. It contributes to severe workforce shortages, with 31 out of 35 physician specialties facing ongoing gaps. Rural areas are hit hardest, and by 2037, non-metro areas are projected to face a 60% shortage of physicians.

Ambient documentation tools, which automate clinical notes, continue to attract significant capital. Companies Ambience, Freed, and [Nabla] earned spots on this year’s list, with Ambience and Nabla securing 11 combined business relationships this year and Freed differentiating through its focus on small clinics, now serving nearly 25,000 clinicians.

tools addressing hospital operations are also making an impact. AssistIQ reduces the time OR staff spend locating and recording surgical supplies, while CalmWave addresses alarm fatigue.

3. AI is becoming embedded in healthcare, but its regulatory environment demands purpose-built infrastructure.

This year’s 50 companies include 47 developing AI solutions, up from 36 in 2024. They are building the compliance, safety, and governance systems critical to AI adoption in healthcare.

Yet, adoption remains hindered by trust gaps. Sooah Cho, Partner at SignalFire, a lead investor in Qualified Health, points to research showing:
“… a lot of providers, like 84%, had lacked confidence in ability to trust AI

Addressing these concerns requires AI systems purpose-built for healthcare’s unique requirements. Hippocratic AI is developing large language models designed specifically for healthcare with clinical safety validation, recognizing that general-purpose AI can’t meet the stringent requirements of regulated environments where errors have serious consequences.

Equally critical is the infrastructure that enables safe AI deployment. Companies are building platforms for AI governance and oversight (Qualified Health), clinical data abstraction (Carta Healthcare), and patient consent management (HealthEx).

4. Voice AI agents are healthcare’s new front door, automating phone-based workflows from patient scheduling to insurance verification calls.

Voice AI is one of the fastest-growing areas in AI development — platforms have raised nearly $400M in funding in 2025 and account for the fastest-growing headcounts among early-stage genAI companies.

Companies are deploying voice AI agents for appointment scheduling and care navigation (Assort Health), billing inquiries (Hyro), ongoing patient engagement (Kouper Health, Ellipsis Health), and post-discharge follow-ups (Hippocratic AI). These systems handle high-volume routine interactions 24/7

The technology is also automating time-intensive administrative tasks for providers, including calling insurance companies for benefit verification and prior authorizations (Infinitus Systems, Mandolin)